PB4010 Biomaterials and Tissue Engineering Syllabus:
PB4010 Biomaterials and Tissue Engineering Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVES:
The objective of this course is to
Acquire knowledge on biomaterials and its applications
Enable the students to learn the aspects of tissue engineering
Get information about the applications of tissue engineering
UNIT I BIOMATERIALS
Biomaterials: Properties of biomaterials-Surface, bulk, mechanical and biological- Scaffolds & tissue engineering – Types of biomaterials-biological and synthetic materials- Biopolymers Applications – Modifications – Nanotechnology in biomaterials.
UNIT II BASIC BIOLOGY OF STEM CELLS
Stem Cells: Introduction- hematopoietic differentiation pathway -Potency and plasticity of stem cells- Stem Cell markers- Types and sources of stem cell with characteristics: embryonic- adult- haematopoietic- fetal- cord blood-placenta- bone marrow-primordial germ cells- cancer stem cells.
UNIT III TISSUE ENGINEERING
Introduction to tissue engineering: Basic definition-current scope – cell numbers and growth rates- measurement of cell characteristics –morphology- number viability- motility and functions. Measurement of tissue characteristics – appearance- cellular component-ECM component- physical properties.
UNIT IV TISSUE REPAIR
Tissue types and Tissue components, Tissue repair and Engineering -wound healing and sequence of events – Cell-Matrix- Cell-Cell Interactions – telomeres and Self renewal Control of cell migration in tissue engineering.
UNIT V CLINICAL APPLICATIONS AND ETHICAL ISSUES
Stem cell therapy-Molecular therapy – In vitro Organogenesis-Neuro degenerative diseases spinal cord injury- heart disease- diabetes- burns and skin ulcers- muscular dystrophy orthopaedic applications – Patent protection and regulation of tissue engineered product sethical issues.
TOTAL: 45 PERIODS
COURSE OUTCOMES:
Upon completion of this course, the students would get
1. Awareness about the properties and broad applications of biomaterials
2. Overall exposure to the role of tissue engineering and stem cell therapy in organogenesis
3. Knowledge of tissue engineering principles
4. Ability to understand the tissue components and tissue repair
5. Opportunity to get familiarized with the stem cell characteristics and their relevance in medicine
6. to know the applications of Biomaterials and Tissue Engineering
REFERENCES:
1. Bernhard O.Palsson, Sangeeta N.Bhatia, ”Tissue Engineering” Pearson Publishers 2009.
2. Meyer, U.; Meyer, Th.; Handschel, J.; Wiesmann, H.P. Fundamentals of Tissue Engineering and Regenerative Medicine. 2009.
3. R. Lanza, J. Gearhart et al (Eds), Essential of Stem Cell Biology, Elsevier Academic press, 2006.
4. J. J. Mao, G. Vunjak-Novakovic et al (Eds), Translational Approaches in Tissue Engineering & Regenerative Medicine” Artech House, INC Publications, 2008
5. Bernard N. Kennedy (editor), Stem cell transplantation, tissue engineering, and cancer applications, New York: Nova Science Publishers, 2008.
6. Raphael Gorodetsky, Richard Schäfer Stem cell- based tissue repair, Cambridge: RSC publishing, 2011.