PB4001 Nanobiotechnology Syllabus:
PB4001 Nanobiotechnology Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVES:
The course aims to
provide fundamental concepts in nanomaterials and their use with biocomponents to synthesize and address larger systems.
provides perspective for students who are interested in nanoscale physical and biological systems and their applications in medicine.
UNIT I INTRODUCTION TO NANOSTRUCTURES
Carbon Nanotubes (CNT), Fullerenes (C60, C300) Nano Peapods Quantum Dots and Semiconductor Nanoparticles, Metal-based Nanostructures (Iron Oxide Nanoparticles), Nanowires, Polymer-based Nanostructures (Dendrimers), Gold Nanostructures:(Nanorods, Nanocages, Nano shells)
UNIT II PROTEIN-BASED NANOSTRUCTURES
Nanomotors: Bacterial (E. coli) and Mammalian (Myosin family), Nano biosensors: Science of Self-assembly – from Natural to Artificial Structures (Biological Nanomotors – Biologically Inspired Hybrid Nanodevices) .Engineered Nanopores.
UNIT III NANOSTRUCTURES FOR ANALYTICS
Nanoparticles for Electrochemical Bioassays – Luminescent Semiconductor Quantum Dots in Biology – Nanoscale Localized Surface Plasmon Resonance Biosensors – Cantilever Array Sensors for Bioanalysis and Diagnostics – Bio nanoarrays
UNIT IV 3-D BIO -PRINTING (THREE-DIMENSIONAL BIO-PRINTING)
Introduction – History, principle and its components, Classification of 3D bio-printing techniques – Extrusion-based bio-printing, Droplet-based bio-printing, Laser-based bioprinting, Design Requirements for 3D Bio-printing- Magnetic Resonance Imaging, Computed Tomography, Computer-Aided Design Based Systems, 3D modelling software, Bio inks for 3D bio-printing – Applications of 3D Bio-printing and future trends.
UNIT V NANOMEDICINE AND NANOSENSING
Promising nanobiotechnologies for applications in medicine – Liposomes in nanomedicine – Therapeutic applications of nanomedicine – Nano- Sized carriers for drug delivery and drug carrier systems – Protein and peptide nanoparticles, DNA based nanoparticles, Lipid matrix nanoparticles for drug delivery – Design and development of bionanosensors using DNA, enzymes – Nanobiosensors for imaging and diagnosis.
TOTAL: 45 PERIODS
COURSE OUTCOMES:
1. understand varied nanostructures
2. understand protein-based nanostructures
3. explore the nanotechnology for bioanalysis and diagnostics
4. understanding of most recent advances in Nanobiotechnology with novel Techniques.
5. know nano-based drug delivery and nanomedicine
6. explain the interaction between biomolecules and nanoparticle surface and its applications
REFERENCES:
1. Nanobiotechnology: Concepts, Applications and Perspectives, Christ of M. Niemeyer (Editor), Chad A. Mirkin (Editor) , Wiley-VCH; 1 edition, 2004.
2. Nanobiotechnology II More Concepts and Applications Edited by Chad A. Mirkin and Christof M. Niemeyer. Wiley-VCH; 1 edition, 2007.
3. Nano Biotechnology: Bio Inspired Devices and Materials of the Future by Oded Shoseyovand Ilan Levy, Humana Press; 1 edition 2007.
4. 3D Bio-printing -Fundamentals, Principles and Applications, Ibrahim T. Ozbolat, Academic Press, (2016).
5. 3D Bio-printing in Regenerative Engineering, Principles and Applications, Ali Khademhosseini, Gulden Camci-Unal, 1st edition, CRC press, (2018).
6. Bio-Nanotechnology Concepts and applications. Madhuri Sharon, Maheshwar Sharon, Sunil Pandey and Goldie Oza, Ane Books Pvt Ltd, 1 edition 2012