NT4011 Nanotoxicology Syllabus:

NT4011 Nanotoxicology Syllabus – Anna University PG Syllabus Regulation 2021

OBJECTIVES:

 To make students learn various concepts of toxicity, and its effects.
 To help them gain knowledge about the toxicity in Nanoscience, and their effects on Human.
 To enhance knowledge on the nanotoxicology – prevention and remedies.

UNIT I INTRODUCTION TO TOXICOLOGY

Concept of Toxicology-Types of toxicity based on route of entry, nature of the toxin. Toxicodynamics–Dose vs Toxicity Relationships. Toxico kinetics – ADME, LADMET hypothesis. Genotoxicity and carcinogenicity – Mechanisms and Tests. Organ toxicity – Respiratory, dermal, hepato, neuro and nephro.

UNIT II NANOTOXICOLOGY

Characteristics of Nanoparticles that determine Potential Toxicity. Bio-distribution of nanoparticles. Interation of Nanoparticles with Biomembrane and genes. Evaluation of Nanoparticle transfer using placental models. Nanomaterial toxicity – Pulmonary, dermal, hepato, neuro, ocular and nephro; Estimation of Nanoparticle Dose in Humans. In vitro toxicity studies of ultrafine diesel exhaust particles; Toxicity studies of carbon nanotubes

UNIT III PROTOCOLS IN TOXICOLOGY STUDIES

Methods for toxicity assessment – Cyto, Geno, hepato, neuro, nephrotoxicity. Assessment of toxicokinetics. Assessment of oxidative stress and antioxidant status.

UNIT IV ANIMAL MODELS

Types, species and strains of animals used in toxicity studies. Dosing profile for animal models. Studies on toxicology, pathology and metabolism in mouse and rat. Laws and Regulations Governing Animal Care and Use in Research.

UNIT V RISK ASSESSMENT AND EXECUTION

SRisk assessment of Nanoparticle exposure. Prevention and control of nanoparticles exposure. Regulation and recommendations.

TOTAL : 45 PERIODS

COURSE OUTCOMES:

CO1: Students will get knowledge on nanotoxicology and their effects on human and animals
CO2: They will acquire knowledge about various prevention methods
CO3: Gaining knowledge on the remedies for nanotoxicology

REFERENCES:

1. John H. Duffus, Howard G. J. Worth, ‘Fundamental Toxicology’, The Royal Society of Chemistry 2006.
2. Nancy A. Monteiro-Riviere, C. Lang Tran., ‘Nanotoxicology: Characterization, Dosing and Health Effects’,Informa Healthcare publishers, 2007.
3. Lucio G. Costa, Ernest Hodgson, David A. Lawrence, Donald J. Reed,William F.Greenlee ‘Current Protocols in Toxicology’, John Wiley & Sons, Inc. 2005.
4. Shayne C. Gad, ‘Animal models in toxicology’, Taylor & Francis Group, LLC 2007.
5. P. Houdy, M. Lahmani, F. Marano, ‘Nanoethics and Nanotoxicology’, Springer- Verlag Berlin Heidelberg 2011.
6. A Reference handbook of nanotoxicology by M.Zafar Nyamadzi 2008.
7. Andreas Luch, ‘Molecular, Clinical and Environmental Toxicology Volume 2: Clinical Toxicology’, Birkhauser Verlag AG 2010.