NT4007 Advanced Drug Delivery Systems Syllabus:
NT4007 Advanced Drug Delivery Systems Syllabus – Anna University PG Syllabus Regulation 2021
OBJECTIVES:
To learn about Fundamentals of drug delivery systems
To study the materials and techniques used in Delivery systems
To learn about Recent development in the area of devices and therapy.
UNIT I THEORY OF ADVANCED DRUG DELIVERY
Fundamentals of Nanocarriers – Size, Surface, Magnetic and Optical Properties, Pharmacokinetics and Pharmacodynamics of Nano drug carriers. Critical Factors in drug delivery. Transport of Nanoparticles – In Vitro and Ex Vivo Models.
UNIT II POLYMERS
Dendrimers- Synthesis -Nanoscale containers- Dendritic Nano scafold systems-Biocompatibility of Dendrimers, Gene transfection. pH based targeted delivery- chitosan and alginate. Copolymers in targeted drug delivery- PCL,PLA, PLGA.
UNIT III LIPID BASED NANOCARRIERS
Liposomes, niosomes and solid lipid nanoparticles. Ligand based delivery by liposomes. Cubosomes.
UNIT IV MICROBES AND ANTIBODY BASED NANOCARRIERS
Bacterial dependent delivery of vaccines. Drug delivery and subcellular targeting by virus, Drug packaging and drug loading. Delivery of therapeutics by antibodies and antibody bioconjugates.
UNIT V DEVICES FOR DRUG DELIVERY
Fabrication and Applications of Microneedles, Micropumps, microvalves. Implantable microchips.
TOTAL : 45 PERIODS
COURSE OUTCOMES:
CO1: Students will gain knowledge in basics of drug delivery systems
CO2: Students will gather idea about materials and techniques used for drug coating and delivery
CO3: Students will acquire information about recent trends equipments and delivery systems
REFERENCES:
1. M. Salzman Drug Delivery: Engineering Principles for Drug Therapy, Oxford University Press, 2001.
2. A.M. Hillery, Drug Delivery and Targeting, CRC Press, 2002.
3. B. Wang, Drug Delivery: Principles and Applications, Wiley Intersceince, 2005.
4. Ram B. Gupta, Uday B. Kompella , Nanoparticle Technology for Drug Delivery, Taylor & Francis, 2006.