MX4008 Tissue Engineering and Immuno Engineering Syllabus:
MX4008 Tissue Engineering and Immuno Engineering Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVES:
To understand basics of tissue engineering
To learn basics of cell mechanics in tissue engineering
To know the importance of biomaterials in tissue engineering
To understand basics of Immunology
To understand the importance of applied immunology for therapy
UNIT I INTRODUCTION TO TISSUE ENGINEERING
History and scope of tissue engineering – Scientific and Social Challenges – Structure and organization of Tissues – Development of Tissue – Cell and Extracellular matrix interaction – Morphogenesis and Tissue Engineering – Cell Determination and Differentiation
UNIT II FUNDAMENTALS OF CELL MECHANISMS
Cell adhesion, Cell migration and Cell aggregation – Cell growth and Cell cycle. Cellular Interactions: Cell – Cell and Cell – Matrix. Control of Cell migration in Tissue Engineering –Cell delivery and Recirculation – Cell Culture in vitro – 3D culture in Tissue Engineering – In vitro Organogenesis – Cell transplantation.
UNIT III BIOMATERIALS IN TISSUE ENGINEERING
Biological vs Nonbiological materials – Extra Cellular Matrix – Collagen, Chitin & Degradable and Nondegradable materials – Polymer, Ceramics and Metals – Cell interaction with different materials –- Scaffolds – Control releaser agents in Tissue Engineering – Cell interaction with suspension and gels – Tissue response to implants
UNIT IV INTRODUCTION TO IMMUNOLOGY
Introduction of Immunology – Antigen; Antibody; Cytokine; Heparin; Histamine; Innate and Adaptive Immunity. Immune Recognition – Immune Effectors function – Immune Regulation – Immune memory. Introduction of Stem cells – Induced Pluripotent Stem cells – Stem cell identification – Surface markers & FACS analysis
UNIT V APPLIED IMMUNOLOGY
Introduction – Inflammation – microorganisms survival strategies – Vaccines – Newer approaches to vaccine development – Immunization against cancer – Immune Responses – Pathogens, Cancer and Biomaterials. Immunotherapy
TOTAL:45 PERIODS
COURSE OUTCOMES:
CO1: Define the statement of tissue engineering in healthcare
CO2: Explain the invitro organization of tissue culture
CO3: Explain different methods involved in characterization and preparation of biomaterials in tissue engineering
CO4: Explain different types of stem cells and its application in tissue engineering
CO5: Explain the basics of immunology in human being
CO6: Explain the applications of immuno engineering to healthcare sector
REFERENCES
1. R.Lanza, J.Gearhart et.al,(Eds), Essential of Stem cell Biology, Elsevier Academic Press, 2nd edition 2009.
2. Robert P. Lanza, Robert Langer and Joseph Vacanti., Principles of Tissue Engineering, 2nd Edition, Academic press, Elsevier 2013.
3. Gary E Wnek, Gary L Browlin – Encyclopedia of Biomaterials and Biomedical Engineering – Marcel Dekker Inc New York, 2nd edition, 2008.
4. SujataV.Bhatt, Biomaterials (2nd Edition), Narosa Publishing House, 2005.
5. W. Mark Saltzman Tissue Engineering – Engineering Principles for Design of Replacement Organs and Tissue, Oxford University Press Inc. New York, 2004
6. Peter J Delves, Seamus J Martin, Dennis R Burtn and Ivan M Roitt., Roitts Essential Immunology, 13th Edition, Wiley –Blackwell, 2016
7. Judith a Owen, Jenni Punt and Sharon A Stranford, Kuby Immunology, Macmillan Internation, 7th Edition, 2012
8. Ananthanarayan and Paniker. Textbook of Microbiology, Eleventh Edition. Himayatnagar, Hyderabad : Orient Longman