MX4004 Biomaterials Syllabus:
MX4004 Biomaterials Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVES:
To introduce concepts of materials and interaction of surfaces towards biomaterials.
To learn about the polymeric materials and composites in tissue replacements.
To study the various techniques involved in controlling the microbial growth on the surfaces.
To understand diverse elements controlling biological responses to materials.
To know the compatibility and functioning of artificial organs inside the living system.
UNIT I INTRODUCTION
Definition of biomaterials, mechanical properties, surface chemistry of materials, surface modification, Tissue Reaction, Wound Kinetics, Bio Compatibility.
UNIT II MATERIALS IN MEDICAL DEVICES
Metals, Ceramics, Polymers and Biomimetic Materials, Composites. Material preparation, chemical composition, properties, uses in medicine and biosciences and failure mechanisms.
UNIT III STERILIZATION OF BIOMATERIALS
Sterilization techniques: Process and mechanism of action of steam sterilization, radiation sterilization, electron beam sterilization, ethylene oxide, chlorine dioxide and plasma gas sterilization
UNIT IV TESTING OF MATERIALS
Testing with Tissue Culture – in vitro and in vivo assessment of biocompatibility, Testing with Soft Tissues and testing at non Thrombogenic surface – blood compatibility and thrombogenicity, ISO 10993- standard for assessment of biocompatibility.
UNIT V HARD AND SOFT REPLACEMENT
Cardiac Implants, Orthopedic Implants, Neuro Muscular Implants, Transcutaneous Implants, Intraocular lenses.
COURSE OUTCOMES:
On completion of this course the student will be able to:
CO1: Understand the basic principles in material science and their contribution towards Biomedical engineering
CO2: Analyze different types of materials and apply them in designing a device
CO3: Select the materials for designing an implant in tissue replacement
CO4: Identify significant gaps required to overcome challenges and further developments
CO5: Critically review papers from the scientific journals and identify areas of research opportunities
TOTAL:45 PERIODS
REFERENCES
1. J.H.U.Brown (Ed), Advances in BioMedical Engineering, Academic Press 1975.
2. Andrew F.Von Racum, HandBook of Bio Medical Evaluation, Mc-Millan Publishers, 1980.
3. Jacob Cline, HandBook of BioMedical Engineering, Academic Press in Sandiego, 1988.
4. Jonathan Black, Biological Performance of Materials- Fundamentals of biocompatibility, 4th Edition, CRC Press 2005.
5. Larry L. Hench and Julian R.Jones, Biomaterials, Artificial organs and Tissue Engineering, 2005.
6. Buddy D.Ratner, Allan S .Hoffman, Frederick J. Schoen, Jack E. Lemons, Biomaterial Science; An Introduction to Materials in Medicine,2nd Edition, Elsevier Academic Press, San Diego, 2004.