MX4001 Nanotechnology and its Applications Syllabus:
MX4001 Nanotechnology and its Applications Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVES:
To understand the essential features of biology and nanotechnology that are converging to create the new areas of bio nanotechnology and nanomedicine.
To understand the principles behind nanomedicine and the applications of nanomaterials in medicine.
To understand the need, problem and solutions for polymeric, lipidous and solid nanosized drug delivery systems.
To impart the knowledge to apply the nanomaterials in different medical applications.
To know the underlying concept in engineering and implement in nano centric applications
UNIT I INTRODUCTION OF NANOPARTICLES
Overview of nanotechnology from a medical perspective, different types of nano biomaterials and nanostructure interactions. Synthesis and characterization of smart nanomaterials, surface modification, biofunctionalization of nanomaterials.
UNIT II NANOMATERIALS AND NANOENGINEERING
Lipid- based (liposomes, micelles, solid lipid nanoparticles) and magnetic based particles and their delivery for biomedical applications. Inorganic nanoparticles, carbon- based (fullerenes, buckyballs and carbon nanotubes), biodistribution and its fate.
UNIT III NANOTECHNOLOGY IN DRUG DELIVERY
Nanoshells, nanopores, Tectodendrimers, active and passive cell targeting, viral based drug delivery system-nanoparticle drug system for oral administration, drug system for nasal administration, drug system for ocular administration, nanotechnology in diagnostic application. Preformulation studies: on various dosage forms such as tablets, capsule, suspension, creams, emulsion, injectables ophthalmic and aerosols etc.
UNIT IV NANOTECHNOLOGY IN IMAGING, DIAGNOSTIC AND DETECTION
Nuclear imaging systems –SPECT and PET, advanced MR imaging, optical imaging and CT. Ultrasound imaging and therapy, nanoimaging systems, micro/nano fluidics, diagnostics, and biosensors.
UNIT V APPLICATION IN CANCER THERAPY
Introduction and rationale for nanotechnology in cancer therapy – passive targeting of solid tumors and active targeting strategies in cancer, Pharmacokinetics of nanocarrier-mediated drug and gene delivery – multifunctional nanoparticles for cancer therapy- neutron capture therapy of cancer: Nanoparticles and high molecular weight boron delivery agents. Nanooncology, nano neurology, nanocardiology, nano-orthopedics and nano-Ophthalmology.
COURSE OUTCOMES:
On completion of this course the student will be able to:
CO1: Understand latest scientific developments and discoveries in the field of Nanomedicine.
CO2: Understand the toxicological aspects of Nano sized particles.
CO3: Understand basic stem cell biology and corresponding requirement for tissue engineering.
CO4: Follow the new findings in the area of Nanomedicine and implement the perspectives in own research.
CO5: Understand new approaches in nanotechnology that can be used in biomedical therapies.
TOTAL:45 PERIODS
REFERENCES
1. CM, Niemeyer C.A. Mirkin., Nanobiotechnology – Concepts, Applications and Perspectives – 2004, Wiley – VCH.
2. Nicholas A. Kotov, Nanoparticle Assemblies and Superstructures. 2006 -CRC.
3. Nano: The Essentials: T. Pradeep. McGraw – Hill education – 2007.
4. Challa, S.S.R. Kumar, Josef Hormes, Carola Leuschner, Nanofabrication towards Biomedical Applications, Techniques, Tools, Applications and Impact.2005, Wiley – VCH.
5. Kewal K. Jain, The Handbook of Nanomedicine. Humana Press, (2008).
6. Zhang, Nanomedicine, A Systems Engineering Approach 1st Ed., Pan Stanford Publishing, (2005).
7. Robert A. Freitas Jr., Nanomedicine Volume IIA: Biocompatibility, Landes Bioscience Publishers, (2003).