BY4102 Bioprocess Technology Syllabus:
BY4102 Bioprocess Technology Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVES:
To impart knowledge on black box stoichiometries principles applicable in Biotechnology
To impart knowledge on design and operation of fermentation processes with all its prerequisites.
To endow the students with the basics of microbial kinetics, metabolic stoichiometry and energetics.
To develop bioengineering skills for the production of biochemical product using integrated biochemical processes.
To develop learning and understanding ability in case studies for fermentation derived products
UNIT I BLACK BOX MODEL
Yield coefficients, black box stoichiometries, elemental balances, heat balance, degrees of reduction balances, systematic analysis of black box stoichiometries, and identification of gross measurement errors
UNIT II DESIGN OF FERMENTATION PROCESSES
Kinetics of substrate utilization, biomass growth and product formation, inhibition of cell growth and product formation. Design and operation of continuous cultures, chemostat in series, batch and fed batch cultures, total cell retention cultivation.
UNIT III MODELING OF VARIOUS FERMENTATION PROCESSES
Principles of model building for biotechnological processes, unstructured models on the population level, structured models on the cellular level, morphologically structured model, genetically structured models, cybernetic model, modeling of recombinant systems.
UNIT IV BIOREACTOR DESIGN & CONSTRUCTION
Basic design and construction of CSTR, bioreactor design of agitator / agitator motor, power consumption in aerated bioreactor, design of sparger, mixing time estimation, oxygen mass transfer capability in bioreactor, Removal of Heat in bioreactor, Main parameters to be monitored and controlled in fermentation processes.
UNIT V CASE STUDIES IN FERMENTATION DERIVED PRODUCTS
Case studies on Production of green chemicals, algal biofuels, recombinant Insulin. Case studies on medium design, reactor design & process optimization.
TOTAL: 45 PERIODS
COURSE OUTCOMES:
After completion of the course the students will be able to
CO1 Gain knowledge on black box stoichiometries principles applicable in Biotechnology
CO2 Understand the design and operation of fermentation processes with all its prerequisites.
CO3 Gain knowledge in basics of microbial kinetics, metabolic stoichiometry and energetics.
CO4 Develop bioengineering skills for the production of biochemical product using integrated biochemical processes.
CO5 Develop learning and understanding ability in case studies for fermentation derived products
REFERENCES:
1. Shuler, M.L., Kargi F., “Bioprocess Engineering – Basic Concepts “, Prentice Hall, 2nd Edition, 2015.
2. Pauline D., “Bioprocess Engineering Principles “. Elsevier, 2nd Edition, 2012.
3. Nielsen, J. and Villadsen, J. “Bioreaction Engineering Principles”. Springer, 3rd Edition, 2011.
4. Lydersen B.K., “Bioprocess Engineering Systems, Equipment and Facilities” , Wiley Blackwell, 2nd Edition, 2010.
5. Bailey, J.E. and Ollis, D.F. “Biochemical Engineering Fundamentals”, 2nd Edition, McGraw Hill, 2017.
6. Stanbury, P.F., Stephen J.H., Whitaker A., “Principles of Fermentation Technology”, Science & Technology Books, 2nd Edition, 2009.