BY4071 Biomaterials and Tissue Engineering Syllabus:
BY4071 Biomaterials and Tissue Engineering Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVES:
1 To learn the fundamentals of tissue engineering and tissue repairing
2 To educate the role of Biomaterials in Tissue engineering applications
3 To acquire knowledge of applicability of molecular agents in drug delivery systems which promote tissue engineering principles.
4 To acquire knowledge on clinical applications of tissue engineering
5 To understand the basic concept behind tissue engineering focusing on the stem cells.
UNIT I FUNDAMENTAL OF TISSUE ENGINEERING
Cell cycle – Stem cells – Types, factors influencing stem cells – Mechanical properties of cells and tissues, cell adhesion – Extracellular matrix – Glycans, laminin, fibronectin, collagen, elastin, extracellular matrix functions – Signalling – Mechanics and receptors – Ligand diffusion and binding, trafficking and signal transduction – In vitro cell proliferation.
UNIT II BIOMATERIALS FOR TISSUE ENGINEERING
Introduction to Biomaterials – classification- significance.in tissue engineering based therapies, Modifications of Biomaterials, Measurement of protein adsorption – Direct and indirect methods, fibrinogen adsorption – Displaceable and non-displaceable – Changes in protein conformation upon adsorption – Vroman effect principle to maximize the amount of fibrinogen adsorption – Devices for tissue engineering transplant cells.
UNIT III DELIVERY OF MOLECULAR AGENTS AND CELL INTERACTIONS WITH POLYMERS
Molecular agents in tissue engineering – Controlled released of agents – Methods, in time and space – Future applications of controlled delivery – Microfluidic systems – Microfluidics and microfluidic devices – Cell interactions – Factors influencing cell interactions – Cell interactions with polymer surfaces and suspension – Cell interactions with three-dimensional polymer.
UNIT IV BIOMATERIALS AND CONTROLLED DRUG DELIVERY
Biomaterials: Properties of biomaterials ,Surface, bulk, mechanical and biological properties .Natural and synthetic biodegradable Polymers – Engineered tissues – Skin regeneration – Nerve regeneration – Liver, cartilage, bone – Biodegradable polymers in drug delivery –Polymeric drug delivery systems – Applications of biodegradable polymers, Recent advancements of Nanotechnology based biomaterials in targeted and controlled drug delivery .
UNIT V BIOPOLYMER- BASED BIOMATERIALS AS SCAFFOLDS AND STEM CELLS
Natural polymers – Structural and chemical properties, scaffold processing, mechanical properties and biodegradability – Biocompatibility and host response – Application of scaffolds in tissue engineering. Use of stem cells in tissue engineering – Embryonic stem cells, mesenchymal stem cells (MSC), adult stem cells, markers for detection of stem cells – Risks with the use of stem cells. Applications of macro, micro and nano sized commercially available biomaterials for stem cell therapy.
TOTAL: 45 PERIODS
COURSE OUTCOMES:
After completion of the course the students will be able to
CO1 Understand the components of the tissue architecture .
CO2 Gain depth knowledge about the role of Biomaterials in Tissue engineering applications
CO3 Awareness about the properties and broad applications of biomaterials.
CO4 Understand stem cell characteristics and their relevance in Medicine.
CO5 Overall exposure to the role of tissue engineering and stem cell therapy in organogenesis
REFERENCES
1. Pallua, N. and Suscheck, C.V., “Tissue Engineering: From Lab to Clinic” Springer, 2010
2. Palsson, B., Hubbell, J.A., Plonsey, R. and Bronzino, J.D., “Tissue Engineering”, CRC Press, 2003.
3. Palsson, B.O. and Bhatia, S., “Tissue Engineering”, Pearson Prentice Hall, 2004.
4. Saltzman, W.M., “Tissue Engineering”, Oxford University Press, 2004.
5. Scheper, T., Lee, K. and Kaplan, D., “Advances in Biochemical Engineering / Biotechnology – Tissue Engineering I”, Volume 102, Springer-Verlag Berlin Heidelberg, 2006.