BY4014 Bio Nanotechnology Syllabus:
BY4014 Bio Nanotechnology Syllabus – Anna University PG Syllabus Regulation 2021
OBJECTIVES:
The course aims to
Provide concepts of nanotechnology
Have knowledge on the synthesis and characterization of nanomaterials
Have an idea of the potential applications of nano technology in various fields including nanomedicine
UNIT I NANOSCALE PROCESSES AND NANOMATERIALS
Overview of nanoscale processes and characterization of nanomaterials – Physicochemical properties of nanomaterials – Concepts in nanotechnology – Natural nanomaterials –Types of Nanomaterials (Quantum dots, Nanoparticles, Nanocrystals, Dendrimers, Polymeric nanoparticles, Bucky balls, Nanotubes) – Interaction between biomolecules and nanoparticle surface –Synthesis and assembly of nanoparticles and nanostructures using bio-derived templates.
UNIT II STRUCTURAL AND FUNCTIONAL PRINCIPLES OF BIONANOTECHNOLOGY
Biomolecular structure and stability – Protein folding – Self-assembly – Self-organization – Molecular recognition – Flexibility – Information-Driven nano assembly – Energetics – Chemical transformation – Regulation – Biomaterials – Biomolecular motors – Traffic across membranes – Biomolecular sensing – Self-replication – Machine-phase bio nanotechnology.
UNIT III PROPERTIES AND MEASUREMENT OF NANOMATERIALS
Optical Properties: Absorption, Fluorescence, and Resonance; Methods for the measurement of nanomaterials; Microscopy measurements: SEM, TEM, AFM and STM. Confocal and TIRF imaging
UNIT IV NANOBIOLOGY AND BIOCONJUGATION OF NANOMATERIALS
Properties of DNA and motor proteins; Lessons from nature on making nanodevices; Reactive groups on biomolecules (DNA & Proteins); Surface modification and conjugation to nanomaterials. Fabrication and application of DNA nanowires; Nano fluidics to solve biological problems
UNIT V NANOMEDICINE AND NANOSENSING
Promising nanobiotechnologies for applications in medicine – Role of nanotechnology in methods of treatment – Liposomes in nanomedicine – Therapeutic applications of nanomedicine – Nano- Sized carriers for drug delivery and drug carrier systems – Protein and peptide nanoparticles, DNA based nanoparticles, Lipid matrix nanoparticles for drug delivery – Design and development of bio nanosensors using DNA, enzymes – Nano biosensors for imaging and diagnosis.
TOTAL: 45 PERIODS
OUTCOMES:
Upon completing this course, the students
CO1 understand fundamental concepts of nanotechnology and anomaterials
CO2 have knowledge on the fabrication and characterization of nanomaterials
CO3 understand nanobiology and modification of nanomaterials
CO4 know nano-based drug delivery and nanomedicine
REFERENCES
1. Gazit, E., and Mitraki, A., “Plenty of Room for Biology at the Bottom: An Introduction to Bio nanotechnology”, Imperial College Press, 2013.
2. Goodsell, D.S., “Bio nanotechnology”, John Wiley and Sons, 2004.
3. Jesus M. de la Fuente and Grazu, V., “Nanobiotechnology: Inorganic Nanoparticles Vs Organic Nanoparticles” Elsevier, 2012.
4. Niemeyer, C.M. and Mirkin, C.A., “Nanobiotechnology: Concepts, Applications and Perspectives”, Wiley- VCH, 2006.
5. Shoseyov, O. and Levy I., “Nanobiotechnology: Bioinspired Devices and Materials of the Future”, Humana Press, 2008.