BY4010 Bioprocess Modelling and Simulation Syllabus:
BY4010 Bioprocess Modelling and Simulation Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVES
1 To impart knowledge on the fundamental and empirical models for dynamic process
2 To provide knowledge to be able to develop kinetic models for biological process
3 To impart knowledge on the model and design the bioreactors
4 To impart knowledge on the parameters involved in bioprocess
5 To impart knowledge to simulate bioprocess with the help of computation tools
UNIT I INTRODUCTION TO MODELING
Use of mathematical models, principles of formulation, fundamental laws, continuity equations, energy equations, equations of motions, transport equations, equation state, equilibrium, basic chemical kinetics
UNIT II KINETICS AND BIOREACTOR MODELS
Enzyme kinetics- Microbial kinetics-Structured kinetic model-batch, fed Batch and continuous operation Modeling of non-ideal behavior in bioreactors – Tanks-in-series, dispersion and compartment models
UNIT III DESIGN OF BIOREACTORS
Immobilized enzyme Bioreactors; Mass transfer in immobilized bio catalytic systems-Analysis of film and pore diffusion resistances and their effect on overall reaction kinetics; Mass transfer in biological reactors-Inter phase gas-liquid mass transfer, General oxygen balances for gas-liquid transfer- Models for oxygen transfer in large scale bioreactors-Design and analysis of packed bed and membrane bioreactors
UNIT IV MONITORING AND CONTROL OF BIOPROCESSES
Elements of feedback control- types of controller action- Proportional Controller- Proportional Integral Controller – Proportional Derivative Controller- Proportional Integral Derivative Controller-Advanced control strategies- Cascade Control – Feed Forward Control- Bioprocess adaptive control – Bioprocess control using Artificial Intelligence
UNIT V SIMULATION OF BIOPROCESSES
Problem Structuring, Process Analysis, and Process Scheme – Implementation and Simulation Uncertainty Analysis- Software packages for simulation of bioprocesses – MATLAB-SIMULINK, ISIM; Simulation of bioprocesses using models from literature sources
TOTAL: 45 PERIODS
COURSE OUTCOMES:
At the end of the course, the students will be able
CO1 To understand the fundamental and empirical models for dynamic process
CO2 To develop kinetic models for biological process
CO3 To model and design the bioreactors
CO4 To understand the parameters involved in bioprocess
CO5 To simulate bioprocess with the help of computation tools
REFERENCES
1. Dunn I.J., “Biological Reaction Engineering: Dynamic Modeling Fundamentals with Simulation Examples”, Wiley-VCH, 1st Edition, 2003.
2. Luyben W.L., “Process Modeling, Simulation and control for Chemical Engineers”, McGraw Hill, 2nd Edition,2013.
3. Bailey J.A and Ollis D.F., “Biochemical Engineering Fundamentals”, McGraw Hill (New York), 2nd Edition, 2010.
4. Heinzle E, Biwer A.P, Cooney C.L., “Development of Sustainable Bioprocesses: Modeling and Assessment”,John Wiley and sons, 2007.
5. Marlin, T.E., “Process Control”, 2nd edition, McGraw Hill, New York, 2000.
6. Smith C.A., Corripio A.B., “Principles and Practice of Automatic Process Control”, Wiley, New York, 3rd edition,2005.
7. Thomas E.M., “Process Control: Designing Processes and Control Systems for Dynamic Performance”, McGraw Hill, 1st edition, 2000.