BO4202 Immunopharmacology Syllabus:

BO4202 Immunopharmacology Syllabus – Anna University PG Syllabus Regulation 2021

OBJECTIVES

The course aims to,
 Enhance the knowledge pertaining to the function and diseases of the human immune system.
 Learn the strategies of development, classification and application of immunotherapeutic drugs, vaccines and biologicals.
 Explain the mechanism of drug actions at cellular and molecular level
 Discuss the Pathophysiology and pharmacotherapy of certain diseases
 Understand the adverse effects, contraindications and clinical uses of drugs used in treatment of diseases

UNIT I BASICS OF PHARMACOLOGY AND IMMUNOLOGY

Principles of basic and clinical pharmacokinetics and pharmacodynamics of immune drugs; Overview of discovery and development of immuno-drugs and various therapeutic pathways and targets of immune system, immune cell and organ classification, Innate and adaptive immunity, Immunity to virus, bacteria and fungi; neuro humoral regulation of immune responses, complement pathways, cytokine classification and activation, T-cell and B-cell development, bioassay and animal models for immune drug validation.

UNIT II VACCINOLOGY AND IMMUNODIAGNOSTICS

T and B epitopes classification, adjuvant and hapten classification, immuno-screening of antigens, vaccine formulation technology, vaccine production and validation, recombinant vaccines, peptide vaccines, therapeutic vaccines. Concept of reverse vaccinology, Monoclonal antibody production and applications, antibody engineering, scFv Antibodies, immunoconjugates, immunotoxins. Immunodiagnostics– ELISA types, Flow cytometry principle, instrumentation and diagnostic applications, principle/development of Rapid immuno diagnostic tests.

UNIT III IMMUNOTHERAPEUTICS AND CANCER IMMUNOTHERAPY

(WHO) Anatomical Therapeutic Chemical (ATC) Classification and pharmacology of drugs affecting the immune system (L, L01, L02, L03, L04), therapeutic use of cytokines, therapeutic Mabs classification and formulation. Cancer vaccines, CAR T-cell therapy, immune check-point inhibitors.

UNIT IV TRANSPLANTATION

Laws of transplantation, host vs graft and graft versus host reactions; Role of T cell in allograft rejection, HLA Classification, HLA typing and transplantation, general immunosuppressive therapy – Corticosteroids, mitotic inhibitors, fungal metabolites, lymphoid irradiation; Specific immunosuppressive therapy– Mabs, Co stimulatory signal blockers and adjuvant therapies.

UNIT V IMMUNOLOGY OF ALLERGY

Classification of hypersensitivity reactions, Classification of allergens, Drug Hypersensitivity – pharmacologic perspective, immunologic perspective, Off-target toxicity, Cellular Basis, Chemical Basis – The Hapten/pro hapten hypothesis, The Danger theory, The pi concept, therapy and prevention of allergies;. Pharmacology of antihistamines, mast cell stabilizers, anti-inflammatory agents and anti-rheumatoid drugs

TOTAL :45 PERIODS

COURSE OUTCOMES:

At the end of the course the student will be able to,
CO1 gain knowledge on the diseases impacted in the domain of humoral/cellular immune responses.
CO2 apply their knowledge on the pharmacology of drugs affecting the immune system
CO3 develop research skills related to developing and evaluating immunotherapeutics for emerging diseases.

REFERENCES

1. Thomas J. Kindt, Richard A. Goldsby, Barbara A. Osborne, Janis Kuby. “Kuby Immunology”. 6th Edition, W.H. Freeman, 2007.
2. Kenneth Murphy, Casey weaver. “Janeway’s Immunobiology”, 9th Edition, Garland Science, Taylor & Francis Group, 2017.
3. David Male Jonathan Brostoff David Roth Ivan Roitt “Immunology”, 8th Edition, Elsevier, 2012.
4. Laurence Brunton, Bjorn Knollmann, RandaHilal-Dandan, “Goodman and Gilman’s: The Pharmacological basis of therapeutics”, McGraw-Hill Education / Medical, 13th edition, 2017.
5. Karen Whalen, “Lippincott Illustrated Reviews: Pharmacology”, Lippincott Williams and Wilkins, 7th Edition, 2019 Katzung, B.G., “Basic and Clinical Pharmacology”, 14th Edition, McGraw Hill 2017.