BO4017 Human Physiology and Drug Metabolism Syllabus:
BO4017 Human Physiology and Drug Metabolism Syllabus – Anna University PG Syllabus Regulation 2021
OBJECTIVES
To provide fundamental knowledge on human physiology, drug metabolism and biotransformation of drug in human body.
To understand the principles of biotransformation of drugs.
To study the drug metabolism in correlation with the physiology of the body.
UNIT I FOUNDATIONS OF PHYSIOLOGY
Introduction to physiology. Chemical & Physical Foundations. Basic cell physiology-Cell Introduction, Cell Organelles, Cell membrane, Movement of the substances and water through the cell membrane, Bioelectric potentials. Homeostasis – Definition, negative and positive feedback mechanisms – neural & endocrine mechanisms. Endocrine control of organic metabolism, growth and reproduction.
UNIT II PHYIOLOGICAL CONCEPTS
Nervous system-Sensory nervous system, Motor nervous system, Higher functions of the nervous system, Synapse, Reflexes, Cerebrospinal fluid, Blood brain and blood CSF barrier. Properties of cardiac muscles, Conducting system of the heart, Pressure changes during cardiac cycles, Capillary circulation, Arterial and venous blood pressure. Gastro intestinal system – General structure of alimentary canal, Gastric secretion, Pancreatic secretion, Gastric motility-digestive peristalsis Gastrointestinal hormones
UNIT III PHYSIOLOGICAL CONCEPTS
Neuro muscular system – Muscles – Skeletal muscles – Properties of skeletal muscles, Muscular contraction and relaxation, Neuromuscular junction, Sarcotubular system, Smooth muscle – mechanism of contraction. Renal physiology – Nephrones, Juxtra glomerular filtrate, Reabsorption, Secretion-mechanism of secretion, Concentrating and diluting mechanism of urine, Dialysis.
UNIT IV DRUG ABSORPTION AND BIOTRANSFORMATION CONCEPTS
Factors influencing enzyme induction and inhibition; Extraction of drugs; Biliary and fecal excretion; Factors effecting drug metabolism; Drug metabolism in fetus and new born. Biotransformation of drugs; Enzymes responsible for bio-transformations; Microsomal and non-microsomal, mechanisms.
UNIT V DRUG METABOLISM – STUDY MODELS
Models to study drug metabolism; Dose effect relationships; Adverse drug reactions and drug interactions; Toxic reactions; Allergic reactions; Idiosyncrasy; Acute poisoning and its treatment.
TOTAL: 45 PERIODS
OUTCOMES
CO1. Understand the basic principles of cells and endrocrine systems.
CO2. Demonstrate the working principles of Nervous, Cardio vascular and Gastro intestinal systems
CO3. Demonstrate the concepts on Neuro muscular, Renal Physiology systems.
CO4. Explain the drug absorption and biotransformation of drugs in the human physiological systems.
CO5. Acquire the knowledge on drug metabolism in various models.
CO6. Expertise in the course of Human Physiology and Drug Metabolism
REFERENCES
1. Ganong W.F., “Review of Medical Physiology”, 16th Edition, Prentice Hall, 1993.
2. Vander A.J., Sherman, J.H. and Luciano, D.S. “Human Physiology”, McGraw-Hill, 1990.
3. Carola, R., Harley, J.P. and Noback, C.R., ‘Human Anatomy and Physiology’, 2nd Edition, McGraw Hill, 1992
4. Guyton, A.C., “Text book of Medical Physiology”, 9th Edition, Harcourt Brace & Co., 1996.
5. Ross and Wilson, “Human Anatomy and Physiology”, ELBS Edition.? 2007
6. Goodman & Gilman, Laurence L Brunton, The Pharmacological Basis of Therapeutics, 11th Edition, McGraw Hill, 2005.
7. Woolf, Thomas F. “Handbook of Drug Metabolism”. Marcel Dekker, 1999.
8. Human Physiology 15th Edition. Stuart Fox and Krista Rompolski, 2019.
9. C C Chatterjee’s Human Physiology 13ed Vol 1 & 2. Pb 2020.