BO4015 Advances in Pharmacogenomics Syllabus:
BO4015 Advances in Pharmacogenomics Syllabus – Anna University PG Syllabus Regulation 2021
OBJECTIVES
The course aims to,
• Provide knowledge about Pharmacogenomics and drug design using genomic applications.
• Study the genome applications on drug action and toxicity.
• To understand the human genome.
• To understand the correlation between pharmacogenomics and drug design.
UNIT I INTRODUCTION TO PHARMACOGENOMICS
Pharmacogenetics-The roots of pharmacogenomics, Genetic drug response profiles, the effect of drugs on Gene expression, pharmacogenomics in drug discovery and drug development.
UNIT II THE HUMAN GENOME
Expressed sequence Tags (EST) and computational biology, Microbial genomics, computational analysis of whole genomes, computational genome analysis, Genomic Differences that affect the outcome of host pathogen interactions: A template for the future of whole genome-based pharmacological science.
UNIT III ASSOCIATION STUDIES IN PHARMACOGENOMICS
Viability and ADR in drug response: contribution of genetic factor, Multiple inherited genetic factors influence the outcome of drug treatments, Plasma binding proteins, Drug targets.
UNIT IV GENOMICS APPLICATIONS FOR DRUG ACTION AND TOXICITY
Genomics, Proteomics, Bioinformatics, The pharmaceutical process, applications of pharmaceutical industry, Understanding biology and diseases, Target identification and validation, Drug candidate identification and optimization.
UNIT V PHARMACOGENOMICS AND DRUG DESIGN
The need of protein structure information, protein structure and variation in drug targets-the scale of problem, Mutation of drug target s leading to change in the ligand binding pocket.
TOTAL : 45 PERIODS
COURSE OUTCOMES
At the end of the course the student will be able to,
CO1 learn about the human genome, gene expression and their effect on drug therapy and toxicity.
CO2 know about the influence of epigenetic on therapeutic outcome.
CO3 have a complete understanding about the fundamentals of pharmacogenomics and personalized medicine.
REFERENCES
1. Licinio, Julio and Ma-Li Wong, “Pharmacogenomics: The Search for the Individualized Therapies”, Wiley-VCH, 2002.
2. Chiranjib Chakraborty and Atana Bhattacharyya, “Pharmacogenomics: An Approach to New Drugs Development”, 2004.
3. Rothstein, Mark, A. “Pharmacogenomics: Social, Ethical and Clinical Dimensions”, Wiley- Liss, 2003.