BM4009 Tissue Engineering Syllabus:
BM4009 Tissue Engineering Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVES:
To understand basics of tissue engineering
To learn basics of cell mechanics in tissue engineering
To know the importance of biomaterials in tissue engineering:
To understand the importance of stem cell in tissue engineering
To learn the tissue culture applications in human healthcare
UNIT I INTRODUCTION TO TISSUE ENGINEERING
History and scope of tissue engineering – Scientific and Social Challenges – Structure and organization of Tissues – Development of Tissue – Cell and Extracellular matrix interaction – Morphogenesis and Tissue Engineering – Cell Determination and Differentiation
UNIT II FUNDAMENTALS OF CELL MECHANISMS
Cell adhesion, Cell migration and Cell aggregation – Cell growth and Cell cycle. Cellular Interactions: Cell – Cell and Cell – Matrix. Control of Cell migration in Tissue Engineering –Cell delivery and Recirculation – Cell Culture in vitro – 3D culture in Tissue Engineering – In vitro Organogenesis – Cell transplantation.
UNIT III BIOMATERIALS IN TISSUE ENGINEERING
Biological vs Nonbiological materials – Extra Cellular Matrix – Collagen, Chitin & Degradable and Nondegradable materials – Polymer, Ceramics and Metals – Cell interaction with different materials –- Scaffolds – Control releaser agents in Tissue Engineering – Cell interaction with suspension and gels – Tissue response to implants
UNIT IV STEM CELLS IN TISSUE ENGINEERING
Introduction of Stem cells – Hemopoetic Stem cells – Embryonic Stem cells – Adult stem cells – Cancer Stem cells – Cord Blood cells – Induced Pluripotent Stem cells – Stem cell identification – Surface markers & FACS analysis – Differentiation, Dedifferentiation and Immortalization – Application of stem cells in tissue Engineering.
UNIT V TISSUE ENGINEERING APPLICATIONS
Synthetic components – Artificial organs – Joints and dental prostheses – Connective Tissue Engineering – Cardiovascular Tissue Engineering – Neural Tissue Engineering – Cell and Drug Delivery systems
TOTAL : 45 PERIODS
COURSE OUTCOMES:
CO1: Explain the mechanisms involved in interaction of different materials with cells and tissues
CO2: Explain different methods involved in characterization and preparation of biomaterials in tissue engineering
CO3: Apply the knowledge in creating new models in drug delivery systems using synthetic and natural scaffolds
CO4: Explain different types of stem cells and its application in tissue engineering
CO5: Develop new approaches to build new tissues using tissue engineering techniques
CO6: Define the applications of tissue engineering to healthcare
REFERENCES
1. R.Lanza, J.Gearhart et.al,(Eds), Essential of Stem cell Biology, Elsevier Academic Press, 2nd edition 2009.
2. Robert P. Lanza, Robert Langer and Joseph Vacanti., Principles of Tissue Engineering, 2nd Edition, Academic press, Elsevier 2013.
3. Gary E Wnek, Gary L Browlin – Encyclopedia of Biomaterials and Biomedical Engineering – Marcel Dekker Inc New York, 2nd edition, 2008.
4. SujataV.Bhatt, Biomaterials (2nd Edition), Narosa Publishing House, 2005.
5. W. Mark Saltzman Tissue Engineering – Engineering Principles for Design of Replacement Organs and Tissue, Oxford University Press Inc. New York, 2004