PB4003 Molecular Medicine Syllabus:
PB4003 Molecular Medicine Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVES:
To provide an in-depth analysis of molecular medicine and mechanisms of diseases associated with Cardiac, renal endocrine and Nephrons.
UNIT I MOLECULAR BASIS OF DISEASES
Concepts pertaining to the Molecular basis of Infectious disease and metabolic disorders. Human genetics relevant to molecular medicine, single nucleotide polymorphisms, multiple gene polymorphisms, single and multi-gene diseases, gene-environment interactions in disease manifestation, genetic and physical mapping of human genome and identification of diseases gene.
UNIT II MOLECULAR BASIS OF GENETIC DISORDERS
Single-Gene Disorders, Autosomal Dominant Disorders -Polycystic Kidney Disease, Marfan’s Syndrome, Huntington’s Disease .Autosomal Recessive Disorders-Cystic Fibrosis, Phenylketonuria, Gaucher Disease, Ichthyosis, Tay–Sachs Disease.
UNIT III BACTERIAL INFECTIONS, ANTIBIOTIC ACTION AND DRUG RESISTANCE
Principles of Microbial Pathogenesis, Molecular basis of infection and pathogenesis of Bacillus anthracis, Mycobacterium spp., Mechanism of bacterial persistence and survival, Immunological response of Mycobacterial infection, Antibiotic action and resistance mechanisms, Drug resistance – origin (genetic and non-genetic), mechanisms.
UNIT IV MOLECULAR VIROLOGY
Molecular basis of Dengue infection and pathogenesis, molecular biology of Hepatitis A, B, C, D & E, and virulence, molecular Biology of HIV Infection, Influenza Virus, Measles, Mumps, Chicken Pox, Poliomyelitis, Human Papilloma virus (HPV), Rabies, Yellow fever and and Japanese Encephalitis. Anti-viral chemotherapy and viral vaccines.
UNIT V MOLECULAR DIAGNOSTICS
PCR-Based Methods for Mutation Detection, Alternative Methods for Mutation Detection and DNA Sequencing for Disease Association, Microarray Approaches to Gene Expression Analysis, Methods for Analysis of DNA Methylation, Other Clinical Diagnostic Technologies: Flow Cytometry, Medical Cytogenetics, Fluorescence In Situ Hybridization, Immunohistochemistry, Laser Capture Microdissection (FFPE).
TOTAL:45 PERIODS
COURSE OUTCOMES:
Upon successful completion of this course a students will be able to:
1. explain the organizational requirements for the translation of biomedical therapeutics from bench to bedside.
2. debate the impact translational research has had on human health and disease.
3. explain why pharmaceutical companies select particular drug or therapeutic targets for further study.
4. articulate the significance and potential of molecular medical advances in biomedical research.
5. apply the knowledge to decipher the mechanisms of molecular and cell biology.
6. synthesize the ideas for the improvement in the current technology.
REFERENCES:
1. Jameson,J.L.,Francis,S.C.,“PrinciplesofMolecularMedicine”,HumanPress,1998.
2. Ross,D.W.“IntroductiontoMolecularMedicine”,3rdEdition,Springer,2002.
3. Elles, R., Mountfield, R. (2011). Molecular Diagnosis of Genetic Diseases. Springer Publication..
4. Pasternak,J.J.“AnIntroductiontoHumanMolecularGenetics”,2ndEdition,WileyLiss, 2005.
5. Strachan,Tom andAndrewP.Read.“HumanMolecular Genetics,Bios, 1996.