BO4010 Molecular Medicine and Mechanism Syllabus:

BO4010 Molecular Medicine and Mechanism Syllabus – Anna University PG Syllabus Regulation 2021

COURSE OBJECTIVES:

The course aims to,
 Understand the molecular mechanism of the disease and advanced understanding of drug interactions.
 Learn the molecular organisation of different organ systems and its functions.
 Discuss the pathophysiology and pharmacotherapy of certain diseases
 Explain the mechanism of drug actions at cellular and molecular level
 Understand the adverse effects, contraindications and clinical uses of drugs used in treatment of diseases
 Explain the mechanism of drug actions at cellular and molecular level

UNIT I INTRODUCTION TO MOLECULAR MEDICINE

Organization of the Human Genome, Chromosomes and Genes – Recombinant DNA and Genetic Techniques – Transcriptional Control of Gene Expression – transmission of Human Genetic Disease –Human Genome Project – Cell Cycle Oncogenes and Tumor suppressor Genes – Molecular Diagnostic Testing – Genetic Counseling – Transgenic Mice as Models of Disease, Introduction to gene therapy.

UNIT II CARDIOLOGY

Molecular Cardiology Congenital Heart Disease – Inherited Cardiomyopathies – Coronary Atherosclerosis – Endothelium – Derived Nitric Oxide and Control of Vascular Tone – Hypertension – Cardiac Arrhythmias – Cardiovascular Gene Therapy.

UNIT III PULMONOLOGY

Asthma – Cystic Fibrosis – Pulmonary Emphysema – Surfactant Deficiency – Lung Cancer: The Role of Tumor Suppressor Genes – Strategies for controlling the diseases.

UNIT IV ENDOCRINOLOGY

Mechanisms of Hormone Action – Diabetes Mellitus – Pituitary Function and Neoplasia Hormone Deficiency- Disorders –Thyroid Disorders – Disorders of the parathyroid Gland – Congenital Adrenal Hyperplasia– Adrenal Disease – Multiple Endocrine Neoplasia Type, Mechanisms of Hypoglycemia Associated with increased Insulin Production.

UNIT V NEPHROLOGY

Renal Development – Mechanisms of Leukocyte Extravasation – Ischemic Acute Renal Failure – Potassium Secretory Channels in the Kidney – Alport Syndrome – Nephrogenic Diabetes Insipidus – Polycystic Kidney Disease – Renal Neoplasms: Wilms’ Tumor and Renal-Cell Carcinoma.

TOTAL: 45 PERIODS

COURSE OUTCOMES:

At the end of the course, the student will be able to:
CO1. explain the organizational requirements for the translation of biomedical therapeutics from bench to bedside.
CO2. debate the impact translational research has had on human health and disease.
CO3. explain why pharmaceutical companies select particular drug or therapeutic targets for further study.
CO4. articulate the significance and potential of molecular medical advances in biomedical research.
CO5. apply the knowledge to decipher the mechanisms of molecular and cell biology.
CO6. synthesize the ideas for the improvement in the current technology.

REFERENCES:

1. Jameson, J. L., Francis, S.C., “Principles of Molecular Medicine”, Human Press, 1998.
2. Ross, D.W. “Introduction to Molecular Medicine”, 3 rd Edition, Springer, 2002.
3. Ross, D.W. “Introduction to Oncogenes and Molecular Medicine”, Springer, 1998.
4. Pasternak, J.J. “An Introduction to Human Molecular Genetics”, 2 ndEdition, Wiley Liss, 2005.
5. Strachan, Tom and Andrew P. Read. “Human Molecular Genetics, Bios, 1996.