BO4103 Molecular Pharmacology Syllabus:
BO4103 Molecular Pharmacology Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVES:
The course aims to,
Study the mechanism of action of drugs at molecular level and different molecular targets.
Provide advanced knowledge about pharmacology of drugs and toxicology.
UNIT I MOLECULAR MECHANISM OF DRUG ACTION
Basic concepts in molecular pharmacology: agonists, antagonists and inverse agonists; potency, intrinsic activity and efficacy; Transducer mechanisms of receptors; Receptor occupancy theory and cellular signalling systems such as G-proteins, cyclic nucleotides, calcium and calcium binding proteins, phosphatidylinositol. Ion channels and their modulators: measurement of binding and response, Voltage-gated ion channels. G protein-coupled receptors, G proteins and effectors, Mechanism of G protein-mediated signalling: – Wnt, hedgehog and notch; Signal transduction through tyrosine kinases; Receptors regulating gene expression.
UNIT II RECEPTORS AND THEIR MODE OF ACTION
Angiotensin receptors Excitatory amino acid receptors Kinin receptor, Adrenoceptors, Low molecular weight heparins, hirudins and GP IIB/IIIa receptor antagonists, Cholinergic receptors, Dopamine receptors, Serotonin receptors, Hormone receptors, GABA and Benzodiazepine receptors, Opioid receptors, Purinergic receptors, Glutamate receptors.
UNIT III BIOACTIVE MOLECULES
Endogenous bioactive molecules: Cytokines, neuropeptides and their modulators, neuro steroids, nitric oxide, phosphodiesterase enzyme and protein kinase C, arachidonic acid metabolites, COX- 2 regulators and their role in inflammation, endothelium derived vascular substances (NO, endothelins) and their modulators.
UNIT IV OVERVIEW OF DRUGS ACTING ON VARIOUS SYSTEMS
Central nervous system, Autonomic nervous system, Autacoids, Analgesic, Antipyretic, and Anti inflammatory Agents, Renal and cardiovascular system, Anti Infective agents, Hormones, Hematopoietic agents.
UNIT V TOXICOLOGY
Principles of toxicology, Physicochemical, Biochemical and genetic basis of toxicity, principles of toxico kinetics, mutagenesis and carcinogenesis, Acute, sub-acute and chronic toxicity studies according to guidelines. Guidelines and regulatory agencies – CPCSEA, OECD, FDA, ICH, FHSA, EPA, EEC, WHO.
TOTAL: 45 PERIODS
COURSE OUTCOMES:
At the end of the course the student will be able to
CO1 Develop research skills based on the knowledge gained about molecular basis of drug action.
CO2 Provide an insight about bioactive molecules, receptors and different classes of drugs in pharmacology.
CO3 Acquire knowledge on performing toxicity studies with appropriate guidelines.
REFERENCES:
1. Laurence Brunton, Bjorn Knollmann, RandaHilal-Dandan, “Goodman and Gilman’s: The Pharmacological basis of therapeutics”, McGraw-Hill Education / Medical, 13th edition, 2017.
2. Tripathi, K.D. “Essentials of Medical Pharmacology”, Jaypee Brothers Medical Publishers, 8 th edition, 2018.
3. RS Satoskar Nirmala Rege SD Bhandarkar, “Pharmacology and Pharmaco Therapeutics”, Elsevier India, 26 th edition, 2020.
4. Francesco Clementi (Editor), Guido Fumagalli (Editor), “General and Molecular Pharmacology: Principles of Drug Action”, Wiley, 1st edition, 2015.
5. Karen Whalen, “Lippincott Illustrated Reviews: Pharmacology”, Lippincott Williams and Wilkins, 7th Edition, 2019.
6. James Ritter, Rod Flower, Graeme Henderson, Yoon Kong, Loke David, Mac Ewan Humphrey Rang “Rang and Dales Pharmacology”, Elsevier, 9 th edition, 2018.
7. Katzung, B.G., “Basic and Clinical Pharmacology”, 14th Edition, McGraw Hill 2017.