BY4018 Computer Aided Learning of Structure and Function of Proteins Syllabus:

BY4018 Computer Aided Learning of Structure and Function of Proteins Syllabus – Anna University PG Syllabus Regulation 2021

COURSE OBJECTIVES

1 To provide fundamental knowledge on the existence of various structures of proteins
2 To make the students aware of the databases available and also know how the structure affects the function of proteins
3 To know the various classes of proteins
4 To learn to use the databases and do phylogenetic studies
5 To know how protein modification influence the function of proteins

UNIT I COMPONENTS OF PROTEIN STRUCTURE

Introduction to Proteins, structure and properties of amino acids, the building blocks of Proteins, Molecular Interactions and their roles in protein structure and function, Primary Structure – methods to determine and synthesis

UNIT II PROTEIN BIOINFORMATICS

Protein sequence and structural databases, Multiple sequence alignment, Secondary, Tertiary and Quaternary Structure of Proteins; Sequence and Structural Motifs; Protein Folding

UNIT III OVERVIEW OF STRUCTURAL AND FUNCTIONAL PROTEINS

Classes of Proteins and their Structure Function Relationships – alpha, beta, alpha/beta proteins, DNA-binding proteins, Enzymes, IgG, membrane proteins

UNIT IV PROTEIN STRUCTURAL CLASSIFICATION DATABASES

SCOP and CATH. Evolutionary relationships and Phylogenetic Studies

UNIT V PROTEIN MODIFICATIONS

Post translational modifications, Engineering of proteins, Site directed mutagenesis, Fusion Proteins, Chemical derivatization.

TOTAL : 45 PERIODS

COURSE OUTCOMES:

After completion of the course the students will be able to
CO1 Have knowledge on the fundamental structure of proteins
CO2 Analyse how the tertiary and quaternary structures as well as folding patterns influence protein function
CO3 Have knowledge about the the different classes of proteins and their function
CO4 Use databases and do phylogenetic studies
CO5 Understand how protein modifications influence their function

REFERENCES

1. Biochemistry, 3rd Edition by Donald J. Voet, Judith G. Voet, 2004 John Wiley & Sons Publishers, Inc
2. Introduction to Protein Structure, 2nd Edition, Carl Branden and John Tooze, 1999, Garland Publications, New York
3. Proteins – Structures and Molecular Properties, 2nd Edition, Thomas E. Creighton, W. H. Freeman and Company, New York

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