BY4003 Advances in Cancer Biology Syllabus:
BY4003 Advances in Cancer Biology Syllabus – Anna University PG Syllabus Regulation 2021
COURSE OBJECTIVE:
1 To educate about the basics principles of cancer biology
2 To educate about the factors involved in development of carcinogenesis.
3 To understand the basics concepts involved in molecular biology of cancer.
4 To educate the basic mechanism involved in cancer metastasis.
5 To educate the importance of various therapies involved in cancer treatments.
UNIT I PRINCIPLES OF CANCER BIOLOGY
Cancer: Definition, causes, properties, classification, clonal nature – Cell Cycle: Regulation of cell cycle, cell proliferation and apoptosis – Signal transduction pathways –Growth factors, Apoptosis: apoptotic pathways, signal molecules, effects on receptor, signal switches – Modulation of cell cycle in cancer – Mechanism of spread.
UNIT II PRINCIPLES OF CARCINOGENESIS
Cancer risk factors – Theory of carcinogenesis – Chemical carcinogenesis – Physical carcinogenes is: x-ray radiation – mechanisms of radiation carcinogenesis – Stages of cancer: initiation, promotion, progression.
UNIT III MOLECULAR ASPECTS OF CANCER AND ITS METASTASIS
Transformation – Activation of Kinases – Oncogenes – Mechanism of oncogene activation – Retroviruses and oncogenes – Detection of Oncogenes – Oncogenes/proto-oncogene activity – Tumor Suppressor Genes: – Telomerases –- Clinical significances of Invasion –– Metastatic cascade– Recent approach to identify key factors controlling Metastasis.
UNIT IV CANCER SCREENING-DIAGNOSIS AND PREVENTION MODALITIES
Life Style, Dietary Factors and Complementary Medicines (Yoga, Meditation, Acupuncture, Exercise & Probiotics) and their Pathways, Screening Principles, Developing and Evaluating a Cancer Screening Program, Various Screening Modalities for specific types of Cancer, Genetic Counselling, Biomarkers in Tumour Clinical Practice, Circulating and Cellular Tumour Markers, In vivo Tumour Imaging, Advances in Cancer Detection – Detection of Metastasis and Micro metastasis.
UNIT V CANCER THERAPY
Therapy forms – Surgery, Chemotherapy, Radiation therapy – Detection of Cancers – Prediction of Aggressiveness of Cancer ––New approaches of Cancer therapy – Cancer Immuno therapy – Monoclonal antibodies and Cancer Treatment, Gene therapy, Cancer Stem cell Targeted Therapy – Introduction to Personalized Medicine, Therapeutic and Preventive Vaccines. Cancer Clinical Trials – Ethical and Regulatory Affairs. Bio-Nanotechnology based product treatments and Targeted drug delivery systems.
TOTAL: 45 PERIODS
COURSE OUTCOMES:
After completion of the course the students will be able to
CO1 Understand the basics principles of cancer biology.
CO2 Understand the factors involved in development of carcinogenesis.
CO3 Understand the basics concepts involved in molecular biology of cancer.
CO4 Understand the basic mechanism involved in cancer metastasis.
CO5 Understand the importance of various therapies involved in cancer treatments.
REFERENCES:
1. Fialho, A. and Chakrabarty, A., “Emerging Cancer Therapy: Microbial Approaches and Biotechnological Tools” 1st Edition, Wiley, 2010.
2. Pelengaris, S. and Khan, M., “The Molecular Biology of Cancer”, Blackwell Publishing, 2006.
3. Ruddon, R.W., “Cancer Biology”, 2nd Edition, Oxford University Press, 2007
4. Schulz, W.S., “Molecular Biology of Human Cancers – An Advanced Students Text Book”, Springer, 2005.
5. Weinberg, R.A., “The Biology of Cancer”, Taylor & Francis, Garland Science, 2007
6. Molecular Biology of Cancer: Mechanisms, Targets and Therapeutics, Lauren Pecorina, Oxford University Press,2008.
7.The Cell; A Molecular Approach, Geoffrey M Cooper, ASM Press, 2013